Natural Phenethyl Alcohol

Product Name:

Natural Phenethyl alcohol

Synonyms:

RARECHEM AL BD 0140;PHENYL ETHYL ALCHOL;PHENYL ETHYL ALCOHOL;PHENYL ETHANOL;PHENYLETHANOL,2-;PHENETHYL ALCOHOL;(beta-pea);.beta.-Phenylethanol

CAS:

60-12-8

MF:

C8H10O

MW:

122.16

EINECS:

200-456-2

Mol File:

60-12-8.mol

Melting point 

−27 °C(lit.)

Boiling point 

219-221 °C750 mm Hg(lit.)

density 

1.020 g/mL at 20 °C(lit.)

vapor density 

4.21 (vs air)

vapor pressure 

1 mm Hg ( 58 °C)

refractive index 

n20/D 1.5317(lit.)

FEMA 

2858 | PHENETHYL ALCOHOL

Fp 

216 °F

storage temp. 

Store at RT.

solubility 

Miscible with chloroform.

pka

15.17±0.10(Predicted)

form 

Liquid

color 

Clear colorless

Odor

floral odor of roses

PH

6-7 (20g/l, H2O, 20℃)

explosive limit

1.4-11.9%(V)

Water Solubility 

20 g/L (20 ºC)

JECFA Number

987

Merck 

14,7224

BRN 

1905732

Stability:

Stable. Substances to be avoided include strong acids and strong oxidizing agents. Combustible.

InChIKey

WRMNZCZEMHIOCP-UHFFFAOYSA-N

CAS DataBase Reference

60-12-8(CAS DataBase Reference)

NIST Chemistry Reference

Benzeneethanol(60-12-8)

EPA Substance Registry System

Benzeneethanol (60-12-8)

Hazard Codes 

Xn

Risk Statements 

21/22-36/38-36-22

Safety Statements 

26-28-36/37-36/37/39

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

1

RTECS 

SG7175000

Autoignition Temperature

410 °C

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29062990

Hazardous Substances Data

60-12-8(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 1790 mg/kg (Jenner)

Uses

Phenylethyl alcohol is qualitatively and quantitatively one of the most important fragrance substances that belongs to the class of araliphatic alcohols.
Phenylethyl alcohol is used frequently and in large amounts as a fragrance material. It is a popular component in rose-type compositions, but it is also used in other blossom notes. It is stable to alkali and, therefore, ideally suited for use in soap perfumes.

Chemical Properties

Phenethyl alcohol has a characteristic rose-like odor and an initially slightly bitter taste, then sweet and reminiscent of peach.

Occurrence

Reported found (as is or esterified) in several natural products: rose concentrate, rose absolute (60% or more) and rose distillation waters; also found in the essential oils of neroli, ylang-ylang, narcissus, hyacinth, lily, tea leaves, Michelia champaca, Pandamus odoratissimus, Congo and Réunion geranium, tobacco and other oils. It has been identified in wines. It has also been reported found in over 200 foods and beverages including apple, apricot, orange juice, orange peel, many berries, bilberry, cherry, grapefruit, peach, raisin, blackberry, guava, grapes, melon, papaya, asparagus, cabbage, leek, potato, rutabaga, tomato, Mentha oils, cinnamon, ginger, breads, butter, saffron, mustard, mango, many cheeses, butter, milk, cooked chicken, cognac, hop oil, beer, rum, whiskies, cider, sherry, cocoa, coffee, tea, nuts, oats, honey, soybean, coconut meat, avocado, olive, passion fruit, plum, beans, mushroom, starfruit, mango, tamarind, fruit brandies, fig, gin, rice, quince, radish, litchi, sukiyaki, calamus, licorice, buckwheat, watercress, elderberry fruit, kiwifruit, loquat, Tahiti and Bourbon vanilla, mountain papaya, endive, lemon balm, clary sage, shrimps, crab, Chinese quince, lamb’s lettuce, truffle and maté.

Uses

Pharmaceutic aid (antimicrobial). In flavors and perfumery (esp rose perfumes).

Uses

phenethyl alcohol is used to mask odor and also as a preservative.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and eye irritant. Experimental teratogenic effects. Other experimental reproductive effects. Causes severe central nervous system injury to experimental animals. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidzing materials. To fight fEe, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes

Safety

Phenylethyl alcohol is generally regarded as a nontoxic and nonirritant material. However, at the concentration used to preserve eye-drops (about 0.5% v/v) or above, eye irritation may occur. 
LD50 (rabbit, skin): 0.79 g/kg 
LD50 (rat, oral): 1.79 g/kg

Purification Methods

Purify the ethanol by shaking it with a solution of ferrous sulfate, and the alcohol layer is washed with distilled water and fractionally distilled. [Beilstein 6 IV 3067.]

Incompatibilities

Incompatible with oxidizing agents and protein, e.g. serum. Phenylethyl alcohol is partially inactivated by polysorbates, although this is not as great as the reduction in antimicrobial activity that occurs with parabens and polysorbates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (nasal, ophthalmic, and otic preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.