Natural Camphor

Product Name:

Natural Camphor

CAS:

76-22-2

MF:

C10H16O

MW:

152.23

EINECS:

200-945-0

Mol File:

76-22-2.mol

Melting point 

175-177 °C(lit.)

Boiling point 

204 °C(lit.)

density 

0.992

vapor density 

5.2 (vs air)

vapor pressure 

4 mm Hg ( 70 °C)

FEMA 

4513 | dl-CAMPHOR

refractive index 

1.5462 (estimate)

Fp 

148 °F

storage temp. 

Store below +30°C.

solubility 

Soluble in acetone, ethanol, diethylether, chloroform and acetic acid.

form 

neat

explosive limit

0.6-4.5%(V)

optical activity

[α]20/D +0.15 to -0.15°, c = 10% in ethanol

Water Solubility 

0.12 g/100 mL (25 ºC)

JECFA Number

2199

Merck 

14,1732

BRN 

1907611

Henry's Law Constant

(x 10-5 atm?m3/mol): 3.00 at 20 °C (approximate - calculated from water solubility and vapor pressure)

Exposure limits

TLV-TWA 12 mg/m3 (2 ppm), STEL 18 mg/m3 (3 ppm) (ACGIH); IDLH 200 mg/m3 (NIOSH). .

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.

InChIKey

DSSYKIVIOFKYAU-MHPPCMCBSA-N

CAS DataBase Reference

76-22-2(CAS DataBase Reference)

NIST Chemistry Reference

Camphor(76-22-2)

EPA Substance Registry System

Camphor (76-22-2)

Hazard Codes 

F,Xn,Xi

Risk Statements 

11-22-36/37/38-20/21/22

Safety Statements 

16-26-37/39

RIDADR 

UN 2717 4.1/PG 3

WGK Germany 

1

RTECS 

EX1225000

Autoignition Temperature

870 °F

TSCA 

Yes

HazardClass 

4.1

PackingGroup 

III

HS Code 

29142910

Hazardous Substances Data

76-22-2(Hazardous Substances Data)

Toxicity

LD50 orally in mice: 1.3 g/kg (PB293505)

Interactions

There are no known mild, moderate or severe drug interactions associated with Camphor. However, if a doctor or pharmacist suggests that one can use camphor while on certain medications, then they are aware of potential drug interactions and they could be putting the patient on observation. One should always notify their doctor or pharmacist if they have health concerns or questions related to camphor.

Side Effects

Common side effects associated with Camphor include skin irritation and redness, burning sensation in the throat and mouth, vomiting, nausea, Lip dryness, rashes, eczema, seizures, respiratory issues, toxicity, scalp issues and chest problems.
In pregnant or lactating mothers, camphor may result in physical and neurological damage to the developing fetus as it can be absorbed through the placenta. It can also be absorbed through the skin hence it can contaminate milk in lactating women. Camphor is considered exceptionally harmful for people with Parkinson’s disease as it interacts negatively with medications for Parkinson and it can result in high toxicity levels.

Warning

Cinnamomum camphora, Lodine and cemphire should not be prescribed to a person who is allergic to camphor or its constituent ingredients.
Camphor is safe when used appropriately hence one should confirm that its composition in camphor products does not exceed 11%. A skin patch test is highly recommended before application of camphor products onto the skin.
Camphor products should not be applied onto injured or broken skin as toxic levels of the product may be absorbed into the body. Camphor may also induce respiratory issues such as wheezing when inhaled.

Chemical Properties

Both optical isomers are found widely in nature, with (+)-camphor being the more abundant. It is, for example, the main component of oils obtained from the camphor tree C. camphora. Camphor is produced by fractional distillation and crystallization of camphor oil or, synthetically, by dehydrogenation of isoborneol over a copper catalyst.
Due to its characteristic penetrating, slightly minty odor, camphor is only used in perfuming industrial products. It is far more important as a plasticizer.

Chemical Properties

Camphor, C1oH160, also known as d-2-camphanone, Japan camphor, laurel camphor,Formosa camphor,and gumcamphor,is a terpene ketone. It is colourless solid with a characteristic odour that is obtained from the wood and bark of the camphor tree and is soluble in water and alcohol. It has two optically active forms (dextro and levo) and an optically inactive mixture (racemic) of these two forms. Camphor is used in pharmaceuticals,in disinfectants, in explosives,and to harden nitrocellulose plastics.

Chemical Properties

Camphor is a colorless glassy solid. Penetrating, characteristic odor.

Physical properties

Colorless to white, flammable granules, crystals or waxy semi-solid with a strong, penetrating, fragrant or aromatic odor. Odor threshold concentration is 0.27 ppm (quoted, Amoore and Hautala, 1983).

Uses

dl-Camphor is used as a plasticizer for celluloseesters and ethers; in the manufacture ofplastics and cymene; in cosmetics, lacquers,medicine, explosives, and pyrotechnics; andas a moth repellent.

Uses

Antipruritic.

Uses

camphor (Cinnamomum camphora) is credited with anesthetic, antiinflammatory, antiseptic, astringent, cooling, and refreshing properties, and thought to be slightly stimulating to blood circulation and function. once absorbed by the subcutaneous tissue, it combines in the body with glucoronic acid and is released through the urine. Camphor is effective for oily and acne skin treatment, and has a scent similar to eucalyptus. In high concentrations, it can be an irritant and numb the peripheral sensory nerves. natural camphor is derived from an evergreen tree indigenous to Asia, although now its synthetic substitute is often used.

Definition

A ketone occurring naturally in the wood of the cam- phor tree (Cinnamomum camphora).

Definition

A naturally- occurring white organic compound with a characteristic penetrating odor. It is a cyclic compound and a ketone, formerly obtained from the wood of the camphor tree but now made synthetically. Camphor is used as a platicizer for celluloid and as an insecticide against clothes moths.

Definition

camphor: A white crystalline cyclicketone, C10H16O; r.d. 0.99; m.p.179°C; b.p. 204°C. It was formerly obtainedfrom the wood of the Formosancamphor tree, but can now besynthesized. The compound has acharacteristic odour associated withits use in mothballs. It is a plasticizerin celluloid.

Brand name

Anbesol;Cresophene;Dasin;Ddd;Endrine;Makatussin;Mentol sedans sulfamidad;Nasello;Resol;Root bark oil;Spirit of camphor;Tcp;Tetesept;Topic.

World Health Organization (WHO)

Camphor, an aromatic crystalline substance with mild local anaesthetic activity, is available in preparations for both external application and inhalation. The use of such preparations has precipitated convulsions in susceptible infants. This has led several regulatory authorities to require the inclusion of appropriate warnings on labelling.

General Description

A colorless or white colored crystalline powder with a strong mothball-like odor. About the same density as water. Emits flammable vapors above 150°F. Used to make moth proofings, pharmaceuticals, and flavorings.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

Naphthalene, Camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967 p. 68].

Hazard

Evolves flammable and explosive vapors when heated. Eye and upper respiratory tract irri- tant, and anosmia. Questionable carcinogen.

Health Hazard

Vapors of camphor can irritate the eyes, nose,and throat. In humans, such irritation may be felt at >3 ppm concentration. Prolongedexposure can cause headache, dizziness, andloss of sense of smell. Ingestion can causeheadache, nausea, vomiting, and diarrhea,and at high dosages can lead to convulsion,dyspnea, and coma. High dosages can beharmful to gastrointestinal tracts, kidney,and brain.
LD50 value, intraperitoneal (mice): 3000mg/kg.

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Safety Profile

A human poison by ingestion and possibly other routes. An experimental poison by inhalation, subcutaneous, and intraperitoneal routes. A local irritant. Ingestion causes nausea, vomiting, dizziness, excitation, and convulsions. Mutation data reported. Used

Potential Exposure

Camphor, a natural product, is used as a plasticizer for cellulose esters and ethers; it is used in lacquers and varnishes; and in explosives and pyrotechnics formulations. It is used as a moth repellent and as a medicinal.

Source

Major component in pine oil (quoted, Verschueren, 1983). Also present in a variety of rosemary shoots (330–3,290 ppm) (Soriano-Cano et al., 1993), anise-scented basil leaves (1,785 ppm) (Brophy et al., 1993), Iberian savory leaves (2,660 ppm) (Arrebola et al., 1994), African blue basil shoots (7,000 ppm), Greek sage (160–5,040 ppm), Montane Mountain mint (3,395–3,880 ppm), yarrow leaves (45–1,780 ppm), and coriander (100–1,300 ppm) (Duke, 1992).

Shipping

UN2717 Camphor, synthetic, Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN1130 camphor oil, Hazard Class: 3; Labels: 3-Flammable liquid

Incompatibilities

May form explosive mixture with air. Violent, possibly explosive, reaction with strong oxidizers, especially chromic anhydride, potassium permanganate. May accumulate static electrical charges, and may cause ignition of its vapors.

Waste Disposal

ncineration of a solution in a flammable solven.