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Product Name: |
Methyl propyl ketone |
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CAS: |
107-87-9 |
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MF: |
C5H10O |
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MW: |
86.13 |
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EINECS: |
203-528-1 |
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Mol File: |
107-87-9.mol |
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Melting point |
-78 °C |
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Boiling point |
101-105 °C(lit.) |
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density |
0.809 g/mL at 25 °C(lit.) |
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vapor pressure |
27 mm Hg ( 20 °C) |
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FEMA |
2842 | 2-PENTANONE |
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refractive index |
n20/D 1.39(lit.) |
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Fp |
45 °F |
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storage temp. |
Flammables area |
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solubility |
water: soluble72.6g/L at 20°C (OECD Test Guideline 105) |
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form |
Liquid |
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Relative polarity |
0.321 |
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Odor Threshold |
0.028ppm |
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explosive limit |
1.56-8.70%(V) |
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Water Solubility |
43 g/L (20 ºC) |
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λmax |
λ: 330 nm Amax: 1.00 |
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JECFA Number |
279 |
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Merck |
14,6114 |
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BRN |
506058 |
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Henry's Law Constant |
12.30 at 25.00 °C (headspace-GC, Straver and de Loos, 2005) |
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Exposure limits |
TLV-TWA 700 mg/m3 (200 ppm); STEL 875 mg/m3 (250 ppm) (ACGIH). |
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Stability: |
Stable. Highly flammable - note low flashpoint. Incompatible with strong bases, oxidizing agents, reducing agents. |
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CAS DataBase Reference |
107-87-9(CAS DataBase Reference) |
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NIST Chemistry Reference |
2-Pentanone(107-87-9) |
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EPA Substance Registry System |
2-Pentanone (107-87-9) |
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Hazard Codes |
F,Xn |
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Risk Statements |
11-22-36/37/38 |
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Safety Statements |
9-16-29-33-37/39-26 |
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RIDADR |
UN 1249 3/PG 2 |
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WGK Germany |
1 |
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RTECS |
SA7875000 |
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Autoignition Temperature |
941 °F |
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TSCA |
Yes |
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HS Code |
2914 19 90 |
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HazardClass |
3 |
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PackingGroup |
II |
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Hazardous Substances Data |
107-87-9(Hazardous Substances Data) |
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Toxicity |
LD50 orally in rats: 3.73 g/kg (Smyth) |
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Chemical Properties |
2-Pentanone has an ethereal, fruity odor. |
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Chemical Properties |
colourless liquid |
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Chemical Properties |
MPK is a colorless to water-white liquid with a strong odor resembling acetone and ether. |
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Physical properties |
Clear, colorless, very flammable liquid with a characteristic, pungent odor. An odor threshold concentration of 20 ppbv was determined by a triangular odor bag method (Nagata and Takeuchi, 1990). Cometto-Mu?iz et al. (2000) reported nasal pungency threshold concentration ranging from approximately 500 to 3,200 ppm. |
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Uses |
2-Pentanone is a flavoring agent that is a clear liquid, colorless, with flowery odor. it is miscible in alcohol and ether and soluble in water. it is obtained by chemical synthesis. it is also termed methyl propyl ketone. |
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Uses |
Methyl propyl ketone (MPK) is used asa solvent, in organic synthesis, and as aflavoring agent. |
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Uses |
Solvent, substitute for diethyl ketone, flavoring. |
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Definition |
ChEBI: A pentanone carrying an oxo substituent at position 2. |
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Production Methods |
MPK can be manufactured by oxidation of 2-pentanol, from ethylene and methyl acetoacetate, or by distillation of a mixture of calcium acetate and calcium butyrate. Commercial purity can be 90% MPK; however, some commercial materials are a mixture of MPK and diethylketone with small amounts of sec-amyl acetate. |
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Preparation |
By dry distillation of a mixture consisting of calcium acetate and calcium butyrate; also by oxidation of sodium or ammonium n-caproate with H2O2. |
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Aroma threshold values |
Detection: 70 ppb |
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Taste threshold values |
Taste characteristics at 25 ppm: sweet, fruity and banana-like with a fermented nuance. |
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General Description |
A clear colorless liquid with the odor of fingernail polish. Flash point 45°F. Less dense than water and soluble in water. Hence floats on water. Density 0.809 g / cm3. Vapors heavier than air. |
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Air & Water Reactions |
Highly flammable. Soluble in water. |
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Reactivity Profile |
2-Pentanone is incompatible with oxidizing agents, strong bases and reducing agents. Reacts violently with bromine trifluoride . |
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Hazard |
Flammable, dangerous fire risk, explosivelimits in air 1.6–8.2%. Eye irritant and affects pul-monary function. |
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Health Hazard |
Exposure can cause irritation of eyes, nose and throat. |
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Health Hazard |
Inhalation of MPK vapors can cause narcosisand irritation of the eyes and respiratorytract. Chronic poisoning from this compoundis not known. Exposure to 1500 ppm wasseverely irritating to humans and 2000 ppmfor 4 hours was fatal to rats. In guinea pigs5000 ppm produced coma. |
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Fire Hazard |
Flammable liquid; flash point (closed cup) 7°C (45°F); vapor density 3 (air = 1); vapor pressure 27 torr at 20°C (68°F); the vapor can travel a considerable distance to an ignition source and flash back; autoignition tempera[1]ture 452°C (846°F); fire- extinguishing agent: “alcohol” foam; a water spray may be used to absorb the heat and flush the spill away from exposures. MPK forms an explosive mixture with air in the range 1.5–8.2% by volume of air. Heating with oxidizers can cause an explosion (U.S. EPA 1988). |
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Safety Profile |
Moderately toxic by ingestion and intraperitoneal routes. Mildly toxic by skin contact and inhalation. Human systemic effects by inhalation: headache, nausea, irritation of the respiratory passages, eyes, and skin. A skin irritant. Mutation data reported. A hghly flammable liquid. A very dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidzing materials. An explosion hazard in the form of vapor when exposed to heat or flame. To fight fue, use alcohol foam. Mxtures with bromine trifluoride may explode during evaporation. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES |
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Waste Disposal |
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. |
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Raw materials |
Hexanoic acid-->Acetic acid calcium salt-->Ethyl butyrylacetate-->CALCIUM BUTYRATE-->2-Pentanol |
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Preparation Products |
5-(2-ETHOXYPHENYL)-1-METHYL-3-N-PROPYL-1,6-DIHYDRO-7H-PYRAZOLO[4,3-D]-7-PYRIMIDINONE-->1-METHYL-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER-->1-METHYL-4-NITRO-3-PROPYL-1H-PYRAZOLE-5-CARBOXYLIC ACID-->1-Methyl-3-propyl-1H-pyrazole-5-carbohydrazide ,97%-->1-Methyl-5-propyl-1H-pyrazole-3-carboxylic acid amide ,97%-->1-Methyl-3-propyl-1H-pyrazole-5-carboxamide ,97%-->1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLIC ACID-->1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXYLIC ACID-->ETHYL 1-METHYL-5-PROPYL-1H-PYRAZOLE-3-CARBOXYLATE-->ETHYL 2,4-DIOXOHEPTANOATE-->Ketanserin-->5-BROMO-PENTAN-2-ONE |
