Product Description

Methyl propionate Basic information

Description References

Product Name:	Methyl propionate
CAS:	554-12-1
MF:	C4H8O2
MW:	88.11
EINECS:	209-060-4
Mol File:	554-12-1.mol

Methyl propionate Chemical Properties

Melting point	-88 °C
Boiling point	79 °C(lit.)
density	0.915 g/mL at 25 °C(lit.)
vapor density	3 (vs air)
vapor pressure	40 mm Hg ( 11 °C)
refractive index	n20/D 1.376(lit.)
FEMA	2742 \| METHYL PROPIONATE
Fp	43 °F
storage temp.	Flammables area
solubility	H2O: soluble16 parts
form	Liquid
color	Clear colorless
explosive limit	2.5-13%(V)
Water Solubility	5 g/100 mL at 20 ºC
JECFA Number	141
Merck	14,6112
BRN	1737628
Stability:	Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, bases. Readily forms explosive mixtures with air. Moisture sensitive.
CAS DataBase Reference	554-12-1(CAS DataBase Reference)
NIST Chemistry Reference	Propanoic acid, methyl ester(554-12-1)
EPA Substance Registry System	Methyl propionate (554-12-1)

Methyl propionate Safety Information

Hazard Codes	F,Xn
Risk Statements	11-20-2017/11/20
Safety Statements	16-24-29-33
RIDADR	UN 1248 3/PG 2
WGK Germany	1
RTECS	UF5970000
Autoignition Temperature	876 °F
TSCA	Yes
HS Code	2915 50 00
HazardClass	3
PackingGroup	II
Hazardous Substances Data	554-12-1(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: 5000 mg/kg

Methyl propionate Usage

Uses	Methyl propionate is used as a solvent for cellulose nitrate and lacquers, and as a raw material for the production of paints, varnishes and other chemicals such as methyl methacrylate. Due to its fruity smell and taste, it is also used in fragrances and flavoring.
Uses	In organic synthesis.
Preparation	Methyl propionate can be prepared by esterification of propionic acid with methanol. Industrially, it is prepared by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl.
Production Methods	Methyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid .
Production Methods	Methyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid.
Aroma threshold values	Detection: 100 ppb to 8.8 ppm
General Description	A clear colorless liquid. Flash point 28°F. Density about the same as water. Vapors heavier than air. May irritate skin, eyes, and mucous membranes. Used for flavoring and as a solvent.
Air & Water Reactions	Highly flammable. Soluble in water.
Reactivity Profile	Methyl propionate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated with alkali metals and hydrides.
Hazard	Flammable, dangerous fire risk, explosivelimits in air 2.5–13%.
Health Hazard	May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard	HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile	Moderately toxic by ingestion. Mildly toxic by inhalation. A skin irritant. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
Chemical Synthesis	By direct esterification of the acid with methanol in the presence of concentrated H2SO4
Potential Exposure	Used as a solvent; and in making paints, lacquers, and varnishes. Also used in flavorings and fragrances
Shipping	UN1248 Methyl propionate, Hazard Class: 3; Labels: 3-Flammable liquid.
Purification Methods	Wash the ester with saturated aqueous NaCl, then dry it with Na2CO3 and distil it from P2O5. (This removes any free acid and alcohol.) It has also been dried with anhydrous CuSO4. [Beilstein 2 IV 104.]
Incompatibilities	May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Keep away from heat and moisture.

Methyl propionate Preparation Products And Raw materials

Raw materials

Propionic acid

Preparation Products

Metalaxyl-->Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)-->Ramipril-->N-Benzyl-4-piperidone-->1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL-->Procymidone-->Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride-->Benalaxyl-->efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent-->CYANOACRYLIC ACID METHYL ESTER-->Ethyl 2-chloropropionate-->hydrazide-->4-Amino-6-chloropyrimidine-->CARBETAMIDE-->BORONAL-->Methyl 3-methylthiopropionate-->DICLOFOP-METHYL-->CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID DIMETHYL ESTER-->Disperse Red 127

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