Eugenol exists naturally in eugenia oil, basil oil and cinnamon oil and other essential oils.
Product Name: |
Eugenol |
CAS: |
97-53-0 |
MF: |
C10H12O2 |
MW: |
164.2 |
EINECS: |
202-589-1 |
Mol File: |
97-53-0.mol |
|
Melting point |
−12-−10 °C(lit.) |
Boiling point |
254 °C(lit.) |
density |
1.067 g/mL at 25 °C(lit.) |
vapor pressure |
<0.1 hPa (25 °C) |
FEMA |
2467 | EUGENOL |
refractive index |
n20/D 1.541(lit.) |
Fp |
>230 °F |
storage temp. |
0-6°C |
solubility |
2.46g/l |
form |
Liquid |
pka |
pKa 9.8 (Uncertain) |
color |
Clear pale yellow to yellow |
Water Solubility |
slightly soluble |
Sensitive |
Air Sensitive |
JECFA Number |
1529 |
Merck |
14,3898 |
BRN |
1366759 |
Stability: |
Stable. Combustible. Incompatible with strong oxidizing agents. |
InChIKey |
RRAFCDWBNXTKKO-UHFFFAOYSA-N |
CAS DataBase Reference |
97-53-0(CAS DataBase Reference) |
NIST Chemistry Reference |
Eugenol(97-53-0) |
EPA Substance Registry System |
Eugenol (97-53-0) |
Hazard Codes |
Xn,Xi |
Risk Statements |
22-36/37/38-42/43-38-40-43-36/38 |
Safety Statements |
26-36-24/25-23-36/37 |
RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany |
1 |
RTECS |
SJ4375000 |
F |
10-23 |
TSCA |
Yes |
HS Code |
29095090 |
Hazardous Substances Data |
97-53-0(Hazardous Substances Data) |
Toxicity |
LD50 in rats, mice (mg/kg): 2680, 3000 orally (Hagan) |
Production |
be synthesized by chemical method in industry. However, chemical synthesis method produces isomers. Boiling point of two isomers is very close, resulting in difficult separation. So isolation method is the main method at present. |
Chemical synthesis |
Allyl bromide, o-methoxyphenol, anhydrous acetone and anhydrous potassium carbonate are added to the kettle and heated to reflux for several hours. After cooling, dilute with water and then extract with ether. The extract is washed with 10% sodium hydroxide and dried over anhydrous potassium carbonate. Recover diethyl ether and acetone after distillation at atmospheric pressure, and then distill under reduced pressure and collect fraction at 110~113 ℃ (1600Pa), finally we get o-methoxyphenyl allyl ether. The mixture is boiled and refluxed for 1 hour and then cooled. The resulting grease is dissolved in ether and extracted with 10% sodium hydroxide solution. The extract is acidified with hydrochloric acid and extracted with ether. Dry the extract over anhydrous sodium sulfate and recover the ether through air distillation, and finally we get product. We could also get product through one step reaction between o-methoxyphenol and allyl chloride with copper as catalyst at 100 ℃. |
Category |
Pesticide |
Toxic grading |
Moderate toxicity |
Chemical Properties |
colourless to faintly yellow liquid with a strong odour of cloves |
Chemical Properties |
Eugenol is the main component of several essential oils; clove leaf oil and cinnamon leaf oilmay contain>90%.Eugenol occurs in small amounts in many other essential oils. It is a colorless to slightly yellow liquid with a spicy, clove odor. |
Chemical Properties |
Eugenol has a strong aromatic odor of clove and a spicy, pungent taste. It darkens and thickens on exposure to air. |
Preparation Products |
Vanillin-->ISOEUGENOL-->Clove oil-->EUGENOL ACETATE-->Methyl eugenol |
Raw materials |
Potassium carbonate-->CARBON DIOXIDE-->Sodium acetate trihydrate-->Allyl chloride-->Linalool-->Guaiacol-->Allyl bromide-->Eucalyptus Citriodara Oil-->Clove oil-->Basil oil-->LAUREL OIL FROM LAURUS NOBILIS-->White camphor oil-->Allyl ether-->Cassia Aurantium P.E Catechins 8% HPLC-->CINNAMON LEAVES OIL-->OCIMENE-->Violet Leaf Absolute |